1-Bromopropane → HCID 11689848, compound

HRID 2353611Notes

Reaction equation

HRID 2353611 reaction equation
[NH2:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[CH:5][C:4]=1[O:10][CH3:11].Br[CH2:13][CH2:14][CH3:15].[CH3:16][C:17]1([CH3:30])[C@@H:19]2[CH2:20][C:21]3[C:25]([C@H:18]12)=[C:24]([CH3:26])[S:23][C:22]=3[C:27]([OH:29])=O>>[CH3:11][O:10][C:4]1[CH:5]=[C:6]([O:9][CH2:13][CH2:14][CH3:15])[CH:7]=[CH:8][C:3]=1[CH2:2][NH:1][C:27]([C:22]1[S:23][C:24]([CH3:26])=[C:25]2[C:21]=1[CH2:20][C@H:19]1[C:17]([CH3:16])([CH3:30])[C@H:18]12)=[O:29]

Participants

4

Reactant 3

HCID 78401-BromopropaneHCID 534043344-(Aminomethyl)-3-methoxyphenolHCID 57892448(1aS,5aR)-1,1,2-trimethyl-1,1a,5,5a-tetrahydro-3-thia-cyclopropa[a]pentalene-4-carboxylic acid

Product 1

HCID 11689848HCID 11689848, compound

Procedure

(1aS,5aR)-1,1,2-Trimethyl-1,1a,5,5a-tetrahydro-3-thia-cyclopropa[a]pentalene-4-carboxylic acid 2-methoxy-4-propoxy-benzylamide is prepared starting from 4-aminomethyl-3-methoxy-phenol, bromopropane and (1aS,5aR)-1,1,2-trimethyl-1,1a,5,5a-tetrahydro-3-thia-cyclopropa[a]pentalene-4-carboxylic acid in analogy to the procedures given in Example 36. LC-MS: tR=1.13 min, [M+1]+=400.19.

Sources & evidence

ORD record
ord-c48682f39aee40f1a7ab338911d59233
Source dataset
uspto-grants-2010_07
Patent number
US07750040B2

Reaction notes

Loading…