Triethylamine → HCID 59380146, compound

HRID 2353649Notes

Reaction equation

HRID 2353649 reaction equation
[OH:1][CH2:2][C:3]1[CH:8]=[C:7]([N:9]2[CH2:14][CH2:13][O:12][CH2:11][C@@H:10]2[CH3:15])[N:6]=[C:5]([C:16]2[CH:21]=[CH:20][C:19]([NH:22][C:23](=[O:27])[N:24]([CH3:26])[CH3:25])=[CH:18][CH:17]=2)[N:4]=1.C(N(CC)CC)C.[CH3:35][S:36](Cl)(=[O:38])=[O:37]>C(Cl)Cl>[CH3:25][N:24]([CH3:26])[C:23]([NH:22][C:19]1[CH:20]=[CH:21][C:16]([C:5]2[N:6]=[C:7]([N:9]3[CH2:14][CH2:13][O:12][CH2:11][C@@H:10]3[CH3:15])[CH:8]=[C:3]([CH2:2][O:1][S:36]([CH3:35])(=[O:38])=[O:37])[N:4]=2)=[CH:17][CH:18]=1)=[O:27]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 24803006HCID 24803006, compound

Product 1

HCID 59380146HCID 59380146, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3-[4-[4-(Hydroxymethyl)-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]phenyl]-1,1-dimethyl-urea (384 mg) was dissolved in DCM (12 mL) and triethylamine (0.216 mL) and the solution was cooled to 0° C. Methane sulfonyl chloride was added (0.121 mL) and the reaction was stirred for 15 minutes at RT before being concentrated in vacuo to give the desired material.

Workup

  1. concentrationbefore being concentrated in vacuo

Sources & evidence

ORD record
ord-199ef770dd7e461099045f462c96dff0
Source dataset
uspto-grants-2010_07
Patent number
US07750003B2

Reaction notes

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