Triethylamine → HCID 59379893, compound

HRID 2353652Notes

Reaction equation

HRID 2353652 reaction equation
[OH:1][CH2:2][C:3]1[CH:8]=[C:7]([N:9]2[CH2:14][CH2:13][O:12][CH2:11][C@@H:10]2[CH3:15])[N:6]=[C:5]([C:16]2[CH:21]=[CH:20][C:19]([NH:22][C:23]([NH:25][CH3:26])=[O:24])=[CH:18][CH:17]=2)[N:4]=1.C(N(CC)CC)C.[CH3:34][S:35](Cl)(=[O:37])=[O:36]>C(Cl)Cl>[CH3:26][NH:25][C:23](=[O:24])[NH:22][C:19]1[CH:20]=[CH:21][C:16]([C:5]2[N:6]=[C:7]([N:9]3[CH2:14][CH2:13][O:12][CH2:11][C@@H:10]3[CH3:15])[CH:8]=[C:3]([CH2:2][O:1][S:35]([CH3:34])(=[O:37])=[O:36])[N:4]=2)=[CH:17][CH:18]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 24803179HCID 24803179, compound

Product 1

HCID 59379893HCID 59379893, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1-[4-[4-(Hydroxymethyl)-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]phenyl]-3-methyl-urea (1.24 g) was partially dissolved in DCM (30 mL) and triethylamine (0.724 mL) and the solution was cooled to 0° C. Methane sulfonyl chloride was added (0.405 mL) and the reaction was stirred for 15 minutes at RT then concentrated in vacuo to give the desired material.

Workup

  1. concentrationthen concentrated in vacuo

Sources & evidence

ORD record
ord-ec1fc53cd72f462e8a6bc300a7b05dab
Source dataset
uspto-grants-2010_07
Patent number
US07750003B2

Reaction notes

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