反应详情

Tert-butyl (4-{4-[1-methyl-1-(methylsulfonyl)ethyl]-6-morpholin-4-ylpyrimidin-2-yl}phenyl)carbamate (2.6 g, 5.46 mmol) was dissolved in DCM (20 mL) and trifluoroacetic acid (10 mL) was added. The reaction mixture was stirred at room temperature for 2 hours then diluted with DCM (20 mL) and washed with saturated aqueous sodium bicarbonate (20 mL). Organic phase collected, dried over magnesium sulphate, filtered and concentrated in vacuo to give the desired material as a cream solid (2.1 g).

1. washwashed with saturated aqueous sodium bicarbonate (20 mL)
2. customOrganic phase collected
3. dry with materialdried over magnesium sulphate
4. filtrationfiltered
5. concentrationconcentrated in vacuo