Triethylamine → HCID 59379989, compound

Participants

Reaction Steps

3-Cyclopropyl-1-[4-[4-(hydroxymethyl)-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]phenyl]urea (1.83 g) was partially dissolved in DCM (50 mL) and triethylamine (1 mL) and the solution was cooled to 0° C. Methane sulfonyl chloride was added (0.56 mL) and the reaction was stirred for 45 mins at RT. The reaction was then washed with water (10 mL) and the organics dried over magnesium sulphate. The solution was vacuumed to dryness to give the desired material as a yellow solid.

Provenance & Evidence