Triethylamine → HCID 59379989, compound

HRID 2353695Notes

Reaction equation

HRID 2353695 reaction equation
[CH:1]1([NH:4][C:5](=[O:28])[NH:6][C:7]2[CH:12]=[CH:11][C:10]([C:13]3[N:18]=[C:17]([CH2:19][OH:20])[CH:16]=[C:15]([N:21]4[CH2:26][CH2:25][O:24][CH2:23][C@@H:22]4[CH3:27])[N:14]=3)=[CH:9][CH:8]=2)[CH2:3][CH2:2]1.C(N(CC)CC)C.[CH3:36][S:37](Cl)(=[O:39])=[O:38]>C(Cl)Cl>[CH:1]1([NH:4][C:5](=[O:28])[NH:6][C:7]2[CH:12]=[CH:11][C:10]([C:13]3[N:14]=[C:15]([N:21]4[CH2:26][CH2:25][O:24][CH2:23][C@@H:22]4[CH3:27])[CH:16]=[C:17]([CH2:19][O:20][S:37]([CH3:36])(=[O:39])=[O:38])[N:18]=3)=[CH:9][CH:8]=2)[CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 59380142HCID 59380142, compound

Product 1

HCID 59379989HCID 59379989, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3-Cyclopropyl-1-[4-[4-(hydroxymethyl)-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]phenyl]urea (1.83 g) was partially dissolved in DCM (50 mL) and triethylamine (1 mL) and the solution was cooled to 0° C. Methane sulfonyl chloride was added (0.56 mL) and the reaction was stirred for 45 mins at RT. The reaction was then washed with water (10 mL) and the organics dried over magnesium sulphate. The solution was vacuumed to dryness to give the desired material as a yellow solid.

Workup

  1. washThe reaction was then washed with water (10 mL)
  2. dry with materialthe organics dried over magnesium sulphate

Sources & evidence

ORD record
ord-286652fd6ee64236aa4c29d5b29a186a
Source dataset
uspto-grants-2010_07
Patent number
US07750003B2

Reaction notes

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