反应详情

A solution of 5-[4-[(3S)-3-methylmorpholin-4-yl]-6-(methylsulfonylmethyl)pyrimidin-2-yl]-1,3-thiazol-2-amine (1 g, 2.71 mmol), sodium hydrogen carbonate (342 mg), and phenyl chloroformate (0.511 mL) in dioxane was stirred at RT for 2 hours then concentrated in vacuo. The residue was partitioned between DCM and water and the organic layer dried over sodium sulphate and evaporated to give a foam. The foam was triturated with a mixture of hexane and diethyl ether to give the desired material as a white solid (1.1 g).

1. concentrationthen concentrated in vacuo
2. customThe residue was partitioned between DCM and water
3. dry with materialthe organic layer dried over sodium sulphate
4. customevaporated
5. customto give a foam
6. customThe foam was triturated with a mixture of hexane and diethyl ether