5-Aminosalicylic Acid → HCID 9879735, compound

HRID 2353766Notes

Reaction equation

HRID 2353766 reaction equation
[NH2:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=[O:8])[C:5]([OH:11])=[CH:4][CH:3]=1.[F:12][C:13]([F:23])([F:22])[C:14]1[CH:21]=[CH:20][C:17]([CH2:18]Cl)=[CH:16][CH:15]=1>>[F:12][C:13]([F:22])([F:23])[C:14]1[CH:21]=[CH:20][C:17]([CH2:18][NH:1][C:2]2[CH:10]=[C:6]([C:7]([OH:9])=[O:8])[C:5]([OH:11])=[CH:4][CH:3]=2)=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 40755-Aminosalicylic AcidHCID 123096p-Trifluoromethylbenzyl chloride

Product 1

HCID 9879735HCID 9879735, compoundYield 50.3%

Procedure

By following the similar procedure in Synthesis Example 1 by using 5-aminosalicylic acid (500 mg, 3.26 mmole) and 4-(trifluoromethyl)benzyl chloride (760 mg, 3.92 mmole), 510 mg (50% yield) of 5-(4-(trifluoromethyl)benzyl)aminosalicylic acid was obtained as a white solid.: mp>188° C. (decompose).

Workup

  1. customin Synthesis Example 1

Sources & evidence

ORD record
ord-47af4a158645437d91c147791c31f435
Source dataset
uspto-grants-2010_07
Patent number
US07750045B2

Reaction notes

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