Hydrochloric Acid → HCID 68440751, compound

HRID 2353773Notes

Reaction equation

HRID 2353773 reaction equation
Cl.[Br:2][C:3]1[CH:13]=[C:12]([O:14]C(=O)C)[C:11]([O:18][CH3:19])=[CH:10][C:4]=1[CH2:5][NH:6][C:7](=[O:9])[CH3:8]>O1CCOCC1>[Br:2][C:3]1[CH:13]=[C:12]([OH:14])[C:11]([O:18][CH3:19])=[CH:10][C:4]=1[CH2:5][NH:6][C:7](=[O:9])[CH3:8]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68441667HCID 68441667, compound

Product 1

HCID 68440751HCID 68440751, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

10% Aq. hydrochloric acid (2.5 ml) was added to a solution of 2-bromo-4-acetoxy-5-methoxy-N-acetyl-benzylamine 2 (0.45 g, 1.66 mmol) in dioxane (15 ml) and the mixture was refluxed for 2 hours, then cooled and the solvent was concentrated under vacuum and the residue was basified with 10% aq. NaOH. The resulting solid was collected by filtration, washed with cold water and dried to furnish the title compound as white solid in quantitative yield.

Workup

  1. temperaturethe mixture was refluxed for 2 hours
  2. temperaturecooled
  3. concentrationthe solvent was concentrated under vacuum
  4. filtrationThe resulting solid was collected by filtration
  5. washwashed with cold water
  6. customdried

Sources & evidence

ORD record
ord-a92d7690c2324249b7d4963110fb0e4e
Source dataset
uspto-grants-2010_07
Patent number
US07750049B2

Reaction notes

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