Hydrochloric Acid → HCID 68441771, compound

HRID 2353774Notes

Reaction equation

HRID 2353774 reaction equation
[ClH:1].[Br:2][C:3]1[CH:13]=[C:12]([O:14][CH2:15][CH2:16][OH:17])[C:11]([O:18][CH3:19])=[CH:10][C:4]=1[CH2:5][NH:6]C(=O)C>C(O)C>[ClH:1].[Br:2][C:3]1[CH:13]=[C:12]([O:14][CH2:15][CH2:16][OH:17])[C:11]([O:18][CH3:19])=[CH:10][C:4]=1[CH2:5][NH2:6]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68443112HCID 68443112, compound

Product 1

HCID 68441771HCID 68441771, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

37% Hydrochloric acid (0.2 ml) was added to a solution of 2-bromo-4-(2-hydroxyethoxy)-5-methoxy-N-acetyl benzylamine 4 (0.1 g, 0.31 mmol) in abs. ethanol (5 ml) and the mixture was refluxed for 12 hours. After cooling, the solvent was evaporated off under reduced pressure and the residue was recrystallized from a methanol/ethyl ether mixture to afford the title compound as pale yellow solid in quantitative yield.

Workup

  1. temperatureAfter cooling
  2. customthe solvent was evaporated off under reduced pressure
  3. customthe residue was recrystallized from a methanol/ethyl ether mixture

Sources & evidence

ORD record
ord-e90cfee14a5a46e79ee0846a11d49a65
Source dataset
uspto-grants-2010_07
Patent number
US07750049B2

Reaction notes

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