Hydrochloric Acid → HCID 68443745, compound

HRID 2353777Notes

Reaction equation

HRID 2353777 reaction equation
[ClH:1].Br[C:3]1[CH:13]=[C:12]([O:14]C(=O)C)[C:11]([O:18][CH3:19])=[CH:10][C:4]=1[CH2:5][NH:6][C:7](=[O:9])[CH3:8].[OH-].[Na+]>O1CCOCC1>[Cl:1][C:3]1[CH:13]=[C:12]([OH:14])[C:11]([O:18][CH3:19])=[CH:10][C:4]=1[CH2:5][NH:6][C:7](=[O:9])[CH3:8]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 68441667HCID 68441667, compound

Product 1

HCID 68443745HCID 68443745, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

10% Aq. hydrochloric acid (2.5 ml) was added to a solution of 2-chloro-4-acetoxy-5-methoxy-N-acetyl-benzylamine 2 (0.45 g, 1.66 mmol) in dioxane (15 ml) and the mixture was refluxed for 2 hours. After cooling, the solvent was reduced under vacuum and the residue was basified with 10% aq. NaOH. The resulting solid was collected by filtration, washed with cold water and dried to furnish the title compound as white solid in quantitative yield.

Workup

  1. temperaturethe mixture was refluxed for 2 hours
  2. temperatureAfter cooling
  3. filtrationThe resulting solid was collected by filtration
  4. washwashed with cold water
  5. customdried

Sources & evidence

ORD record
ord-cfc2a0eca8d645b7b35dc1b311f6dead
Source dataset
uspto-grants-2010_07
Patent number
US07750049B2

Reaction notes

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