Hydrochloric Acid → HCID 68441964, compound

HRID 2353779Notes

Reaction equation

HRID 2353779 reaction equation
[ClH:1].Br[C:3]1[CH:13]=[C:12]([O:14][CH2:15][CH:16]([OH:19])[CH2:17][OH:18])[C:11]([O:20][CH3:21])=[CH:10][C:4]=1[CH2:5][NH:6]C(=O)C>C(O)C>[ClH:1].[Cl:1][C:3]1[CH:13]=[C:12]([O:14][CH2:15][CH:16]([OH:19])[CH2:17][OH:18])[C:11]([O:20][CH3:21])=[CH:10][C:4]=1[CH2:5][NH2:6]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68441321HCID 68441321, compound

Product 1

HCID 68441964HCID 68441964, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

37% Hydrochloric acid (0.2 ml) was added to a solution of 2-bromo-4-(2-hydroxyethoxy)-5-methoxy-N-acetyl benzylamine 4 (0.1 g, 0.31 mmol) in abs. ethanol (5 ml) and the mixture was refluxed for 12 hours. After cooling, the solvent was evaporated off under reduced pressure and the residue was recrystallized from a mixture of methanol/ethyl ether to afford the title compound as pale yellow solid in quantitative yield.

Workup

  1. temperatureAfter cooling
  2. customthe solvent was evaporated off under reduced pressure
  3. customthe residue was recrystallized from a mixture of methanol/ethyl ether

Sources & evidence

ORD record
ord-6d08deb3f84f4c0ea457e3135a34984b
Source dataset
uspto-grants-2010_07
Patent number
US07750049B2

Reaction notes

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