反应详情

To a mixture of 2-Amino-benzoic acid methyl ester (900 g, 6 mol) in pyridine (6 L) was added p-Toluenesulfonyl chloride (1500 g, 7.5 mol). The mixture was stirred overnight at room temperature. The mixture was poured into ice water, and the resultant precipitates were collected by filtration. The filtrates were dissolved in CH2Cl2, and the solution washed with diluted HCl, H2O, and dried over MgSO4. The residue thus obtained was crystallized from ethanol to give 2-(Toluene-4-sulfonylamino)-benzoic acid methyl ester (1454 g, 80%).

1. customthe resultant precipitates
2. filtrationwere collected by filtration
3. dissolutionThe filtrates were dissolved in CH2Cl2
4. washthe solution washed with diluted HCl, H2O
5. dry with materialdried over MgSO4
6. customThe residue thus obtained
7. customwas crystallized from ethanol