5-[Acetyl-(3,5-bistrifluoromethylbenzyl)amino]-2,3,4,5-tetrahydrobenzo[b]azepine-1-carboxylic acid isopropyl ester → HCID 59003135, compound

HRID 2353899Notes

Reaction equation

HRID 2353899 reaction equation
NC1C([O:12][C:13]([F:16])([F:15])[F:14])=CC=CC=1C(OC)=O.[CH:17]([O:20][C:21]([N:23]1[CH2:29][CH2:28][CH2:27][CH:26]([N:30]([C:46](=[O:48])[CH3:47])[CH2:31][C:32]2[CH:37]=[C:36]([C:38]([F:41])([F:40])[F:39])[CH:35]=[C:34]([C:42]([F:45])([F:44])[F:43])[CH:33]=2)[C:25]2[CH:49]=[CH:50][CH:51]=[CH:52][C:24]1=2)=[O:22])([CH3:19])[CH3:18]>>[C:46]([N:30]([CH2:31][C:32]1[CH:37]=[C:36]([C:38]([F:39])([F:40])[F:41])[CH:35]=[C:34]([C:42]([F:43])([F:44])[F:45])[CH:33]=1)[CH:26]1[CH2:27][CH2:28][CH2:29][N:23]([C:21]([O:20][CH:17]([CH3:19])[CH3:18])=[O:22])[C:24]2[C:52]([O:12][C:13]([F:16])([F:15])[F:14])=[CH:51][CH:50]=[CH:49][C:25]1=2)(=[O:48])[CH3:47]

Participants

3

Reactant 2

HCID 113413065-[Acetyl-(3,5-bistrifluoromethylbenzyl)amino]-2,3,4,5-tetrahydrobenzo[b]azepine-1-carboxylic acid isopropyl esterHCID 53419547Methyl 2-amino-3-(trifluoromethoxy)benzoate

Product 1

HCID 59003135HCID 59003135, compound

Procedure

This compound was prepared utilizing the same methodology described in Example 1 wherein replacement of 2-amino-benzoic acid methyl ester with methyl 2-amino-3-trifluoromethoxybenzoate following the procedure of Example 1, Steps 1-8 for the synthesis of 5-[acetyl-(3,5-bistrifluoromethylbenzyl)amino]-2,3,4,5-tetrahydrobenzo[b]azepine-1-carboxylic acid isopropyl ester. CI MS 601 (M+H).

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-aa27a0d7fca5408e9f82536d51b9a1a4
Source dataset
uspto-grants-2010_07
Patent number
US07749992B2

Reaction notes

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