HCID 178418361, compound → Didanosine

Participants

Reaction Conditions

Reaction Steps

2′,3′-Dideoxy-2′,3′-didehydroinosine sodium salt (50 gm) is added to water (180 ml) and stirred for 20 minutes at 25-35° C. Then the contents are hydrogenated under nitrogen atmosphere at 1.5-2.0 kg/cm2 hydrogen pressure at 15-20° C. using raney nickel catalyst for 7-8 hours. The reaction mass is filtered on a celite bed and washed with water (25 ml). To the filtrate activated carbon (2 gm) is added and stirred for 20 minutes. The mass is filtered on a celite bed and washed with water (25 ml). The filtrate is cooled to 5-15° C., the pH is adjusted to 7.0-8.0 with dilute hydrochloric acid (13 ml water+13 ml conc. HCl) at 5-15° C. and stirred for 2 hours 30 minutes. Filtered the mass, washed with water (40 ml). The resulting wet cake is added to water (120 ml), the temperature is raised to 65-75° C. and stirred for 20 minutes at the same temperature. The resulting solution is cooled to 25-35° C. and stirred for 1 hour 30 minutes. The reaction mass is then cooled to 10-15° C. and stirred for 1 hour 30 minutes. Filtered the solid, washed with the 40 ml of water and dried at 55-60° C. to give 30.5 gm of didanosine (HPLC Purity: 99.85%).

Provenance & Evidence