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HRID2354041

反应详情

EQUATION

反应方程式

HRID 2354041 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)c1cc(N=C=O)no1
HCID12918838

5-tert-Butyl-3-isocyanato-1,2-oxazole

C8H10N2O2

结构：Nc1ccc(OCc2ccccc2F)cc1
HCID17608056

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)c1cc(NC(=O)Nc2ccc(OCc3ccccc3F)cc2)no1
HCID11463223

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：Cc1ccccc1
溶剂HCID1140

Toluene

C7H8

CONDITIONS

反应条件

温度
80 °C

PROCEDURE

实验过程

4-(2-Fluoro-benzyloxy)-phenylamine (0.12 g, 1 eq) was mixed with 5-tert-Butyl-3-isocyanato-isoxazole (0.9 g 1 eq) and dissolved in dry toluene. The reaction stirred at 80° C. overnight. The solvent was removed and purified by HPLC. Yield: 85 mg (31%), LC/MS [MH+] 384.

WORKUP

后处理

  1. customThe solvent was removed
  2. custompurified by HPLC