HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2354041Generated: October 30, 2026
5-Tert-butyl-3-isocyanato-1,2-oxazole → 1-(4-(2-Fluorobenzyloxy)phenyl)-3-(5-tert-butylisoxazol-3-yl)urea
https://huagongshe.com/reaction/2354041
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 5-Tert-butyl-3-isocyanato-1,2-oxazole | HCID 12918838 | — |
| Reactant | 4-(2-Fluoro-benzyloxy)-phenylamine | HCID 17608056 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1-(4-(2-Fluorobenzyloxy)phenyl)-3-(5-tert-butylisoxazol-3-yl)urea | HCID 11463223 | — |
Reaction Steps
4-(2-Fluoro-benzyloxy)-phenylamine (0.12 g, 1 eq) was mixed with 5-tert-Butyl-3-isocyanato-isoxazole (0.9 g 1 eq) and dissolved in dry toluene. The reaction stirred at 80° C. overnight. The solvent was removed and purified by HPLC. Yield: 85 mg (31%), LC/MS [MH+] 384.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07750160B2 |
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| Source dataset | uspto-grants-2010_07 |
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| ORD ID | ord-d76a736bb085422d88c17402b1e2a835 |
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| Source note | uspto-grants-2010_07 |
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