HCID 59380957, compound → HCID 59380896, compound

HRID 2354042Notes

Reaction equation

HRID 2354042 reaction equation
[OH:1][NH:2][C:3]([C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8]([O:15][CH3:16])=[CH:7][CH:6]=1)=[NH:4].[C:17]([C:21]1[O:25][N:24]=[C:23]([NH:26][C:27](=[O:38])[NH:28][C:29]2[CH:37]=[CH:36][C:32]([C:33](O)=O)=[CH:31][CH:30]=2)[CH:22]=1)([CH3:20])([CH3:19])[CH3:18]>COCCOCCOC>[C:17]([C:21]1[O:25][N:24]=[C:23]([NH:26][C:27]([NH:28][C:29]2[CH:37]=[CH:36][C:32]([C:33]3[O:1][N:2]=[C:3]([C:5]4[C:14]5[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=5)[C:8]([O:15][CH3:16])=[CH:7][CH:6]=4)[N:4]=3)=[CH:31][CH:30]=2)=[O:38])[CH:22]=1)([CH3:20])([CH3:19])[CH3:18]

Participants

4

Reactant 2

HCID 59380957HCID 59380957, compoundHCID 178491257HCID 178491257, compound

Product 1

HCID 59380896HCID 59380896, compound

Reagents, catalysts & solvents 1

HCID 8150DiglymeSolvent

Procedure

N-Hydroxy-4-methoxy-naphthalene-1-carboxamidine (1 g) and 4-[3-(5-tert-Butyl-isoxazol-3-yl)-ureido]-benzoic acid (1 eq) were reflued in diglyme (5 mL) for 24 h and then purified to give 100 mg of 1-(5-tert-Butyl-isoxazol-3-yl)-3-{4-[3-(4-methoxy-naphthalen-1-yl)-[1,2,4]oxadiazol-5-yl]-phenyl}-urea.

Workup

  1. custompurified

Sources & evidence

ORD record
ord-5959e812b8da4048b1096fdc3795912b
Source dataset
uspto-grants-2010_07
Patent number
US07750160B2

Reaction notes

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