HCID 68688967, compound → HCID 58816579, compound

HRID 2354050Notes

Reaction equation

HRID 2354050 reaction equation
C(OC([N:11]1[CH2:16][CH2:15][C:14]([C:23](=[O:33])[N:24]([CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH3:25])([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:13][CH2:12]1)=O)C1C=CC=CC=1>CO.[Pd]>[CH2:26]([N:24]([CH3:25])[C:23]([C:14]1([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:13][CH2:12][NH:11][CH2:16][CH2:15]1)=[O:33])[C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1

Participants

4

Reactant 1

HCID 68688967HCID 68688967, compound

Product 1

HCID 58816579HCID 58816579, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 4-(benzyl-methyl-carbamoyl)-4-phenyl-piperidine-1-carboxylic acid benzyl ester (4.4 g, 10 mmol) and Pd—C (10%, 400 mg) in MeOH (200 mL) is hydrogenated at r.t. and atmospheric pressure for 3 h. The mixture is filtered and evaporated. The residue is purified by reversed phase MPLC to provide the title compound.

Workup

  1. customis hydrogenated at r.t.
  2. filtrationThe mixture is filtered
  3. customevaporated
  4. customThe residue is purified by reversed phase MPLC

Sources & evidence

ORD record
ord-c12a40028b7f409996e28469f398a70e
Source dataset
uspto-grants-2010_07
Patent number
US07750161B2

Reaction notes

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