1,1'-Carbonyldiimidazole → 1,3-Bis-(2,6-dimethyl-pyridin-4-yl)-urea

Participants

Role	Name	HCID	Charge
Reactant	1,1'-Carbonyldiimidazole	HCID 68263	—
Reactant	4-Amino-2,6-dimethylpyridine	HCID 77047	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	1,3-Bis-(2,6-dimethyl-pyridin-4-yl)-urea	HCID 59381191	—

Reaction Conditions

Temperature	80 °C

Reaction Steps

2,6-Dimethyl-pyridin-4-ylamine (1.22 g, 10 mmol) is dissolved in dry dioxane (30 mL) and CDI (891 mg, 5.5 mmol) is added. The mixture is heated at 80° C. for 1 h. Further CDI (160 mg) is added and stirring is continued for 15 h. The mixture is evaporated and purified by FC (SiO2, EtOAc-MeOH) to provide the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07750161B2
Source dataset	uspto-grants-2010_07
ORD ID	ord-7c12712d647c41eca694e7eb3004b719
Source note	uspto-grants-2010_07