4-Amino-2,6-dimethylpyridine → HCID 58816582, compound

HRID 2354065Notes

Reaction equation

HRID 2354065 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([NH2:8])[CH:5]=[C:4]([CH3:9])[N:3]=1.[F:10][C:11]1[C:16]([O:17][C:18](=O)[O:19]C2C(F)=C(F)C(F)=C(F)C=2F)=[C:15]([F:32])[C:14]([F:33])=[C:13]([F:34])[C:12]=1[F:35]>C1COCC1>[F:10][C:11]1[C:16]([O:17][C:18](=[O:19])[NH:8][C:6]2[CH:5]=[C:4]([CH3:9])[N:3]=[C:2]([CH3:1])[CH:7]=2)=[C:15]([F:32])[C:14]([F:33])=[C:13]([F:34])[C:12]=1[F:35]

Participants

4

Reactant 2

HCID 770474-Amino-2,6-dimethylpyridineHCID 2734833Dipentafluorophenylcarbonate

Product 1

HCID 58816582HCID 58816582, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

A solution of 2,6-dimethyl-pyridin-4-ylamine (Example C1.2., 1.23 g, 10 mmol) in THF (30 mL) is slowly added to a cooled (−10° C.) solution of bis(pentafluorophenyl)carbonate (3.94 g, 10 mmol) in THF (10 mL). The mixture is stirred at r.t. for 48 h and the solution of title compound is used as stock solution for subsequent coupling reactions.

Sources & evidence

ORD record
ord-4d906dc282bc43fd92539e4103e97ebe
Source dataset
uspto-grants-2010_07
Patent number
US07750161B2

Reaction notes

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