2-Chloroethyl isocyanate → 1-(2-Chloro-ethyl)-3-(2,6-dimethyl-pyridin-4-yl)-urea

HRID 2354068Notes

Reaction equation

HRID 2354068 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([NH2:8])[CH:5]=[C:4]([CH3:9])[N:3]=1.[Cl:10][CH2:11][CH2:12][N:13]=[C:14]=[O:15]>C1COCC1>[Cl:10][CH2:11][CH2:12][NH:13][C:14]([NH:8][C:6]1[CH:5]=[C:4]([CH3:9])[N:3]=[C:2]([CH3:1])[CH:7]=1)=[O:15]

Participants

4

Reactant 2

HCID 160352-Chloroethyl isocyanateHCID 770474-Amino-2,6-dimethylpyridine

Product 1

HCID 588165671-(2-Chloro-ethyl)-3-(2,6-dimethyl-pyridin-4-yl)-urea

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2,6-Dimethyl-pyridin-4-ylamine (Example C1.2., 1.22 g, 10 mmol) is dissolved in dry THF (30 mL) and 1-chloro-2-isocyanato-ethane (1.06 g, 10 mmol) is added. The mixture is stirred at r.t. for 15 h. The mixture is evaporated and the residue purified by MPLC to provide the title compound.

Workup

  1. customThe mixture is evaporated
  2. customthe residue purified by MPLC

Sources & evidence

ORD record
ord-3dff6f7deb624cda9eab4aace40bcc7a
Source dataset
uspto-grants-2010_07
Patent number
US07750161B2

Reaction notes

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