HCID 68692193, compound → HCID 11271100, compound

HRID 2354078Notes

Reaction equation

HRID 2354078 reaction equation
[CH2:1]([C:8]1([OH:34])[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][NH:16][C:17]([NH:19][C:20]2[CH:25]=[CH:24][N:23]=[C:22](/[CH:26]=[CH:27]/[C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[CH:21]=2)=[O:18])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CO.[Pd]>[CH2:1]([C:8]1([OH:34])[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][NH:16][C:17]([NH:19][C:20]2[CH:25]=[CH:24][N:23]=[C:22]([CH2:26][CH2:27][C:28]3[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=3)[CH:21]=2)=[O:18])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 68692193HCID 68692193, compound

Product 1

HCID 11271100HCID 11271100, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A suspension of 1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-[2-((E)-styryl)-pyridin-4-yl]-urea (Example 19., 47.0 mg, 0.1 mmol) and Pd—C (10%, 10 mg) in MeOH (10 mL) is stirred under hydrogen atmosphere for 15 h. The catalyst is filtered off and the reaction mixture evaporated to provide the title compound.

Workup

  1. filtrationThe catalyst is filtered off
  2. customthe reaction mixture evaporated

Sources & evidence

ORD record
ord-63db95ebecc9449199d9432c24034ada
Source dataset
uspto-grants-2010_07
Patent number
US07750161B2

Reaction notes

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