HCID 58816578, compound → HCID 11398024, compound

HRID 2354082Notes

Reaction equation

HRID 2354082 reaction equation
FC1C(O[C:9](=[O:20])[NH:10][C:11]2[CH:16]=[C:15]([CH3:17])[N:14]=[C:13]([CH2:18][CH3:19])[CH:12]=2)=C(F)C(F)=C(F)C=1F.[NH2:25][CH2:26][CH2:27][N:28]1[CH2:33][CH2:32][CH:31]([N:34]([CH2:45][CH2:46][CH3:47])[S:35]([C:38]2[CH:43]=[CH:42][C:41]([F:44])=[CH:40][CH:39]=2)(=[O:37])=[O:36])[CH2:30][CH2:29]1>>[CH2:18]([C:13]1[CH:12]=[C:11]([NH:10][C:9](=[O:20])[NH:25][CH2:26][CH2:27][N:28]2[CH2:33][CH2:32][CH:31]([N:34]([CH2:45][CH2:46][CH3:47])[S:35]([C:38]3[CH:39]=[CH:40][C:41]([F:44])=[CH:42][CH:43]=3)(=[O:36])=[O:37])[CH2:30][CH2:29]2)[CH:16]=[C:15]([CH3:17])[N:14]=1)[CH3:19]

Participants

3

Reactant 2

HCID 58816578HCID 58816578, compoundHCID 68689288HCID 68689288, compound

Product 1

HCID 11398024HCID 11398024, compound

Procedure

To a solution of (2-ethyl-6-methyl-pyridin-4-yl)-carbamic acid pentafluorophenyl ester (Example C13., 0.2M, 3 mL, 0.6 mmol) is added a solution of N-[1-(2-amino-ethyl)-piperidin-4-yl]-4-fluoro-N-propyl-benzenesulfonamide (Example B6., 182 mg, 0.53 mmol). The mixture is stirred at r.t. for 15 h. The mixture is evaporated and the residue purified by HPLC to provide the title compound.

Workup

  1. customThe mixture is evaporated
  2. customthe residue purified by HPLC

Sources & evidence

ORD record
ord-66e02ecfb67f4ccda021ae730536ca25
Source dataset
uspto-grants-2010_07
Patent number
US07750161B2

Reaction notes

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