2-(3,4-Dichlorophenyl)acetyl chloride → HCID 58816581, compound

HRID 2354084Notes

Reaction equation

HRID 2354084 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]([NH:11][CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][CH:17]([NH:20][CH3:21])[CH2:16][CH2:15]2)=[O:10])[CH:5]=[C:4]([CH3:22])[N:3]=1.[Cl:23][C:24]1[CH:25]=[C:26]([CH2:31][C:32](Cl)=[O:33])[CH:27]=[CH:28][C:29]=1[Cl:30]>C(Cl)Cl>[Cl:23][C:24]1[CH:25]=[C:26]([CH2:31][C:32]([N:20]([CH:17]2[CH2:16][CH2:15][N:14]([CH2:13][CH2:12][NH:11][C:9]([NH:8][C:6]3[CH:5]=[C:4]([CH3:22])[N:3]=[C:2]([CH3:1])[CH:7]=3)=[O:10])[CH2:19][CH2:18]2)[CH3:21])=[O:33])[CH:27]=[CH:28][C:29]=1[Cl:30]

Participants

4

Reactant 2

HCID 27581492-(3,4-Dichlorophenyl)acetyl chlorideHCID 58816577HCID 58816577, compound

Product 1

HCID 58816581HCID 58816581, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To a cooled (0° C.) mixture of 1-(2,6-dimethyl-pyridin-4-yl)-3-[2-(4-methylamino-piperidin-1-yl)-ethyl]-urea (Example E1., 0.3 mmol) and TEA (0.5 mL, 0.35 mmol) in CH2Cl2 (2 mL) is added a solution of (3,4-dichloro-phenyl)-acetyl chloride (67.0 mg, 0.3 mmol) in CH2Cl2 (1 mL). The mixture is stirred at r.t. for 15 h and evaporated. the residue is purified by HPLC to provide the title compound.

Workup

  1. temperatureTo a cooled
  2. customevaporated
  3. customthe residue is purified by HPLC

Sources & evidence

ORD record
ord-40941c81edcb4d48b61b83a1743ec2bd
Source dataset
uspto-grants-2010_07
Patent number
US07750161B2

Reaction notes

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