HCID 11410496, compound → HCID 11248845, compound

HRID 2354085Notes

Reaction equation

HRID 2354085 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([O:34][CH3:35])=[C:6]([S:8]([N:11]([CH:14]2[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][NH:22][C:23]([NH:25][C:26]3[CH:31]=[C:30]([CH3:32])[N:29]=[C:28]([CH3:33])[CH:27]=3)=[O:24])[CH2:16][CH2:15]2)[CH2:12][CH3:13])(=[O:10])=[O:9])[CH:7]=1>CO.[Pd]>[CH3:32][C:30]1[CH:31]=[C:26]([NH:25][C:23](=[O:24])[NH:22][CH2:21][CH2:20][N:17]2[CH2:18][CH2:19][CH:14]([N:11]([CH2:12][CH3:13])[S:8]([C:6]3[CH:7]=[CH:2][CH:3]=[CH:4][C:5]=3[O:34][CH3:35])(=[O:10])=[O:9])[CH2:15][CH2:16]2)[CH:27]=[C:28]([CH3:33])[N:29]=1

Participants

4

Reactant 1

HCID 11410496HCID 11410496, compound

Product 1

HCID 11248845HCID 11248845, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A suspension of 5-bromo-N-(1-{2-[3-(2,6-dimethyl-pyridin-4-yl)-ureido]-ethyl}-piperidin-4-yl)-N-ethyl-2-methoxy-benzenesulfonamide (Example 99, 30 mg, 0.05 mmol) and Pd—C (10%, 20 mg) in MeOH (10 mL) is stirred under hydrogen atmosphere for 15 h. The catalyst is filtered off and the reaction mixture evaporated to provide the title compound.

Workup

  1. filtrationThe catalyst is filtered off
  2. customthe reaction mixture evaporated

Sources & evidence

ORD record
ord-4ab2423d426042eaa2d8ba5b132cc760
Source dataset
uspto-grants-2010_07
Patent number
US07750161B2

Reaction notes

Loading…