Hydrogen chloride-ethyl acetate → HCID 67128668, compound

HRID 2354091Notes

Reaction equation

HRID 2354091 reaction equation
[C:1]12([CH2:8][N:9]3[CH2:13][CH2:12][C@@H:11]([NH:14]C(=O)OC(C)(C)C)[CH2:10]3)[O:7][CH:4]([CH2:5][CH2:6]1)[CH2:3][CH2:2]2.[ClH:22].CCOC(C)=O>CCOC(C)=O>[ClH:22].[ClH:22].[C:1]12([CH2:8][N:9]3[CH2:13][CH2:12][C@@H:11]([NH2:14])[CH2:10]3)[O:7][CH:4]([CH2:5][CH2:6]1)[CH2:3][CH2:2]2

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 86628130HCID 86628130, compound

Product 1

HCID 67128668HCID 67128668, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of tert-butyl [(3R)-1-(7-oxabicyclo[2.2.1]hept-1-ylmethyl)-3-pyrrolidinyl]carbamate (377 mg) in AcOEt (3.8 mL) was added 4N HCl—AcOEt (3.2 mL), which was stirred at room temperature for 5 hours. The solvent was evaporated. The residue was dried to give (3R)-1-(7-oxabicyclo[2.2.1]hept-1-ylmethyl)-3-pyrrolidinamine dihydrochloride (370 mg) as an orange amorphous.

Workup

  1. customThe solvent was evaporated
  2. customThe residue was dried

Sources & evidence

ORD record
ord-4191c567a4654726ab11e573a5b65195
Source dataset
uspto-grants-2010_07
Patent number
US07750155B2

Reaction notes

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