Hydrochloric Acid → HCID 135900392, compound

HRID 2354102Notes

Reaction equation

HRID 2354102 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][N:10]2[CH2:14][CH2:13][C@@H:12]([NH:15][C:16]3[N:17]=[CH:18][C:19](/[CH:22]=[CH:23]/[C:24]([NH:26][O:27]C4CCCCO4)=[O:25])=[N:20][CH:21]=3)[CH2:11]2)[CH:5]=[CH:6][CH:7]=1.[ClH:34]>CCO>[ClH:34].[ClH:34].[F:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][N:10]2[CH2:14][CH2:13][C@@H:12]([NH:15][C:16]3[N:17]=[CH:18][C:19](/[CH:22]=[CH:23]/[C:24]([NH:26][OH:27])=[O:25])=[N:20][CH:21]=3)[CH2:11]2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86628128HCID 86628128, compound

Product 1

HCID 135900392HCID 135900392, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

A solution of (2E)-3-[5-({(3R)-1-[2-(3-fluorophenyl)ethyl]-3-pyrrolidinyl}amino)-2-pyrazinyl]-N-(tetrahydro-2H-pyran-2-yloxy)acrylamide (160 mg) in EtOH (1.6 mL) was added 2N—HCl solution in EtOH (0.9 mL) and stirred for 3 hours at ambient temperature. The solvent was evaporated in vacuo. To the residue was added IPE. The resulting solid was collected by the filtration to give (2E)-3-[5-({(3R)-1-[2-(3-fluorophenyl)ethyl]-3-pyrrolidinyl}amino)-2-pyrazinyl]-N-hydroxyacrylamide dihydrochloride (116 mg).

Workup

  1. customThe solvent was evaporated in vacuo
  2. additionTo the residue was added IPE
  3. filtrationThe resulting solid was collected by the filtration

Sources & evidence

ORD record
ord-12db0ddfbc174cd59f1f1f77f0565e1f
Source dataset
uspto-grants-2010_07
Patent number
US07750155B2

Reaction notes

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