Hydrochloric Acid → HCID 135900425, compound

Participants

Reaction Steps

To a solution of (2E)-3-[5-({(3R)-1-[3-phenylpropyl]-3-piperidinyl}amino)-2-pyrazinyl]-N-(tetrahydro-2H-pyran-2-yloxy)acrylamide (265 mg) in EtOH (1.5 mL) was added 2N—HCl solution in EtOH (1.5 mL). The reaction mixture was stirred for 2 hours at ambient temperature. IPE (1.5 ml) was added to the mixture. The resulting solid was collected by filtration to give (2E)-N-hydroxy-3-[5-[{(3R)-1-(3-phenylpropyl)-3-piperidinyl}amino]-2-pyrazinyl]acrylamide dihydrochloride (148 mg).

Provenance & Evidence