Hydrochloric Acid → HCID 135900425, compound

HRID 2354105Notes

Reaction equation

HRID 2354105 reaction equation
[C:1]1([CH2:7][CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][CH2:13][C@@H:12]([NH:16][C:17]3[N:18]=[CH:19][C:20](/[CH:23]=[CH:24]/[C:25]([NH:27][O:28]C4CCCCO4)=[O:26])=[N:21][CH:22]=3)[CH2:11]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:35]>CCO>[ClH:35].[ClH:35].[OH:28][NH:27][C:25](=[O:26])/[CH:24]=[CH:23]/[C:20]1[CH:19]=[N:18][C:17]([NH:16][C@@H:12]2[CH2:13][CH2:14][CH2:15][N:10]([CH2:9][CH2:8][CH2:7][C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[CH2:11]2)=[CH:22][N:21]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86628135HCID 86628135, compound

Product 1

HCID 135900425HCID 135900425, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

To a solution of (2E)-3-[5-({(3R)-1-[3-phenylpropyl]-3-piperidinyl}amino)-2-pyrazinyl]-N-(tetrahydro-2H-pyran-2-yloxy)acrylamide (265 mg) in EtOH (1.5 mL) was added 2N—HCl solution in EtOH (1.5 mL). The reaction mixture was stirred for 2 hours at ambient temperature. IPE (1.5 ml) was added to the mixture. The resulting solid was collected by filtration to give (2E)-N-hydroxy-3-[5-[{(3R)-1-(3-phenylpropyl)-3-piperidinyl}amino]-2-pyrazinyl]acrylamide dihydrochloride (148 mg).

Workup

  1. additionIPE (1.5 ml) was added to the mixture
  2. filtrationThe resulting solid was collected by filtration

Sources & evidence

ORD record
ord-57b582af093945e794377657a50772b6
Source dataset
uspto-grants-2010_07
Patent number
US07750155B2

Reaction notes

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