Hydrochloric Acid → HCID 136344088, compound

Participants

Reaction Steps

To a solution of (2E)-3-[5-({(3R)-1-(3-cyclohexylpropyl)-3-pyrrolidinyl}amino)-2-pyrazinyl]-N-(tetrahydro-2H-pyran-2-yloxy)acrylamide (151 mg) in EtOH (0.75 mL) was added 2N—HCl solution in EtOH (0.75 mL) and the reaction mixture was stirred for 2 hours at ambient temperature. The mixture was evaporated and acetone was added. The resulting solid was collected by filtration to give (2E)-3-[5-({(3R)-1-(3-cyclohexylpropyl)-3-pyrrolidinyl}amino)-2-pyrazinyl]-N-hydroxyacrylamide dihydrochloride (117 mg).

Provenance & Evidence