Hydrochloric Acid → HCID 136344088, compound

HRID 2354108Notes

Reaction equation

HRID 2354108 reaction equation
[CH:1]1([CH2:7][CH2:8][CH2:9][N:10]2[CH2:14][CH2:13][C@@H:12]([NH:15][C:16]3[N:17]=[CH:18][C:19](/[CH:22]=[CH:23]/[C:24]([NH:26][O:27]C4CCCCO4)=[O:25])=[N:20][CH:21]=3)[CH2:11]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:34]>CCO>[ClH:34].[ClH:34].[CH:1]1([CH2:7][CH2:8][CH2:9][N:10]2[CH2:14][CH2:13][C@@H:12]([NH:15][C:16]3[N:17]=[CH:18][C:19](/[CH:22]=[CH:23]/[C:24]([NH:26][OH:27])=[O:25])=[N:20][CH:21]=3)[CH2:11]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86628139HCID 86628139, compound

Product 1

HCID 136344088HCID 136344088, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

To a solution of (2E)-3-[5-({(3R)-1-(3-cyclohexylpropyl)-3-pyrrolidinyl}amino)-2-pyrazinyl]-N-(tetrahydro-2H-pyran-2-yloxy)acrylamide (151 mg) in EtOH (0.75 mL) was added 2N—HCl solution in EtOH (0.75 mL) and the reaction mixture was stirred for 2 hours at ambient temperature. The mixture was evaporated and acetone was added. The resulting solid was collected by filtration to give (2E)-3-[5-({(3R)-1-(3-cyclohexylpropyl)-3-pyrrolidinyl}amino)-2-pyrazinyl]-N-hydroxyacrylamide dihydrochloride (117 mg).

Workup

  1. customThe mixture was evaporated
  2. additionacetone was added
  3. filtrationThe resulting solid was collected by filtration

Sources & evidence

ORD record
ord-664d05aaa71e44b9ae2693972114f574
Source dataset
uspto-grants-2010_07
Patent number
US07750155B2

Reaction notes

Loading…