反应详情

温度

150 °C

Disodium 2,3-dimethyl-3-(4-sulphonatobutyl)-3H-indole-5-sulphonate (1.0 g) and 1,4-butanesultone (10 ml) were mixed and heated under nitrogen at 150° C. for 52 hrs to give a dark purple slurry. After cooling, the mixture was triturated with ethyl acetate: the solid portion was collected by filtration, washed with ethyl acetate and diethyl ether, then dried under high vacuum over phosphorus pentoxide to give the title product (1.45 g), which was used directly without purification.

1. customto give a dark purple slurry
2. temperatureAfter cooling
3. customthe mixture was triturated with ethyl acetate
4. filtrationthe solid portion was collected by filtration
5. washwashed with ethyl acetate and diethyl ether
6. dry with materialdried under high vacuum over phosphorus pentoxide