5-Fluoro-2-nitrobenzoic acid → N-[5-[(cyclopropylamino)carbonyl]-2-(trifluoromethyl)phenyl]-5-fluoro-2-nitrobenzamide

HRID 2354156Notes

Reaction equation

HRID 2354156 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:11]=[CH:12][C:13]=1[C:14]([F:17])([F:16])[F:15])[C:5]([NH:7][CH:8]1[CH2:10][CH2:9]1)=[O:6].[F:18][C:19]1[CH:20]=[CH:21][C:22]([N+:28]([O-:30])=[O:29])=[C:23]([CH:27]=1)[C:24](O)=[O:25]>>[CH:8]1([NH:7][C:5]([C:4]2[CH:11]=[CH:12][C:13]([C:14]([F:15])([F:16])[F:17])=[C:2]([NH:1][C:24](=[O:25])[C:23]3[CH:27]=[C:19]([F:18])[CH:20]=[CH:21][C:22]=3[N+:28]([O-:30])=[O:29])[CH:3]=2)=[O:6])[CH2:9][CH2:10]1

Participants

3

Reactant 2

HCID 27374205-Fluoro-2-nitrobenzoic acidHCID 86049018HCID 86049018, compound

Product 1

HCID 69565568N-[5-[(cyclopropylamino)carbonyl]-2-(trifluoromethyl)phenyl]-5-fluoro-2-nitrobenzamide

Procedure

Using an analogous procedure to that described paragraph (A) in the portion of Example 1 which is concerned with the preparation of starting materials, 3-amino-N-cyclopropyl-4-(trifluoromethyl)benzamide was reacted with 5-fluoro-2-nitrobenzoic acid to give N-[5-[(cyclopropylamino)carbonyl]-2-(trifluoromethyl)phenyl]-5-fluoro-2-nitrobenzamide; Mass Spectrum: M−H+ 410.

Sources & evidence

ORD record
ord-69d2b87b62ea43829b384c931fe4f993
Source dataset
uspto-grants-2010_07
Patent number
US07750154B2

Reaction notes

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