Piperidine → N-{5-[(cyclopropylamino)carbonyl)-2-methylphenyl}-2-nitro-5-piperidin-1-ylbenzamide

HRID 2354181Notes

Reaction equation

HRID 2354181 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:7]1([NH:10][C:11]([C:13]2[CH:14]=[CH:15][C:16]([CH3:32])=[C:17]([NH:19][C:20](=[O:31])[C:21]3[CH:26]=[C:25](F)[CH:24]=[CH:23][C:22]=3[N+:28]([O-:30])=[O:29])[CH:18]=2)=[O:12])[CH2:9][CH2:8]1>>[CH:7]1([NH:10][C:11]([C:13]2[CH:14]=[CH:15][C:16]([CH3:32])=[C:17]([NH:19][C:20](=[O:31])[C:21]3[CH:26]=[C:25]([N:1]4[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]4)[CH:24]=[CH:23][C:22]=3[N+:28]([O-:30])=[O:29])[CH:18]=2)=[O:12])[CH2:9][CH2:8]1

Participants

3

Reactant 2

HCID 8082PiperidineHCID 669189745-fluoro-N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-2-nitrobenzamide

Product 1

HCID 66918911N-{5-[(cyclopropylamino)carbonyl)-2-methylphenyl}-2-nitro-5-piperidin-1-ylbenzamide

Procedure

Using an analogous procedure to that described paragraph (A) in the portion of Example 13 which is concerned with the preparation of starting materials piperidine was reacted with N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-5-fluoro-2-nitrobenzamide to give N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-2-nitro-5-piperidin-1-ylbenzamide; NMR Spectrum: (DMSOd6) 0.56 (m, 2H), 0.68 (m, 2H), 1.60 (m, 6H), 2.30 (s, 3H), 2.82 (m, 1H), 3.52 (m, 4H), 7.02 (m, 2H), 7.27 (d, 1H), 7.55 (d, 1H), 7.96 (s, 1H), 8.02 (d, 1H), 8.39 (s, 1H), 9.95 (s, 1H); Mass Spectrum: M+H+ 423.

Sources & evidence

ORD record
ord-a79941ae90744133968a24d14788f0f5
Source dataset
uspto-grants-2010_07
Patent number
US07750154B2

Reaction notes

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