Hydrochloric Acid → HCID 11338653, compound

HRID 2354195Notes

Reaction equation

HRID 2354195 reaction equation
[CH:1]1([NH:4][C:5]([C:7]2[CH:8]=[CH:9][C:10]([CH3:37])=[C:11]([N:13]3[C:22](=[O:23])[C:21]4[C:16](=[CH:17][CH:18]=[C:19]([O:24][C@H:25]5[CH2:29][CH2:28][N:27](C(OC(C)(C)C)=O)[CH2:26]5)[CH:20]=4)[N:15]=[CH:14]3)[CH:12]=2)=[O:6])[CH2:3][CH2:2]1.Cl>O1CCOCC1>[CH:1]1([NH:4][C:5](=[O:6])[C:7]2[CH:8]=[CH:9][C:10]([CH3:37])=[C:11]([N:13]3[C:22](=[O:23])[C:21]4[C:16](=[CH:17][CH:18]=[C:19]([O:24][C@H:25]5[CH2:29][CH2:28][NH:27][CH2:26]5)[CH:20]=4)[N:15]=[CH:14]3)[CH:12]=2)[CH2:2][CH2:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66918881HCID 66918881, compound

Product 1

HCID 11338653HCID 11338653, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Using an analogous procedure to that described paragraph (D) in the portion of Example 18 which is concerned with the preparation of starting materials tert-Butyl (3S)-3-[(3-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-4-oxo-3,4-dihydroquinazolin-6-yl)oxy]pyrrolidine-1-carboxylate was reacted with 4N HCl in dioxane. There was thus obtained the title compound; NMR Spectrum: (DMSOd6) 0.54 (m, 2H), 0.68 (m, 2H), 1.80 (m, 1H), 2.04 (m, 1H), 2.11 (s, 3H), 2.84 (m, 4H), 3.08 (m, 2H), 4.98 (m, 1H), 7.48 (m, 3H), 7.71 (d, 1H), 7.81 (s, 1H), 7.89 (d, 1H), 8.16 (s, 1H), 8.42 (d, 1H); Mass Spectrum: M+H+ 405.

Sources & evidence

ORD record
ord-9fee8af89cc04b9ba37058ca80c54599
Source dataset
uspto-grants-2010_07
Patent number
US07750154B2

Reaction notes

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