反应详情

A solution of 4-bromo-1-(1,3-dithian-2-yl)ethylbenzene (27.2 g, 94 mmol) in tetrahydrofuran (200 ml) was charged with sec-butyllithium (99 ml, 1.3M in cyclohexane, 0.13 mole) dropwise at -78° C. under nitrogen. The mixture was stirred at ambient temperature for 1.5 hours, and then quenched with 1,4-dibromobutane (42 g, 0.2 mole). After being stirred for 3 hours, the mixture was poured into ethyl acetate, and then washed with water and brine. The organic solution was then dried (Na2SO4) and concentrated to an oil. The crude product was purified by flash chromatography over a silica gel column. The 4-(4-bromobutyl)-1-(1,3-dithian-2-yl)-ethylbenzene thus purified was a light oil, 22.3 g.

1. stirringAfter being stirred for 3 hours
2. washwashed with water and brine
3. dry with materialThe organic solution was then dried (Na2SO4)
4. concentrationconcentrated to an oil
5. customThe crude product was purified by flash chromatography over a silica gel column
6. customThe 4-(4-bromobutyl)-1-(1,3-dithian-2-yl)-ethylbenzene thus purified