Hydrochloric Acid → HCID 66918945, compound

Participants

Reaction Steps

To a stirred solution of N-cyclopropyl-3-[6-(4-isopropylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]-4-methylbenzamide (0.010 g) in ethyl acetate (0.5 ml) was added a 4N HCl in dioxane (0.0056 ml) at room temperature. The mixture was stirred at room temperature for a further 30 minutes. The reaction mixture was evaporated to give the title compound; NMR Spectrum: (DMSOd6) 0.55 (m, 2H), 0.70 (m, 2H), 1.24 (m, 6H), 2.13 (s, 3H), 2.85 (m, 1H), 3.00-3.50 (m, 9H), 7.53 (m, 2H), 7.69 (m, 2H), 7.84 (s, 1H), 7.91 (d, 1H), 8.12 (s, 1H), 8.46 (d, 1H), 10.80 (br s, 1H).

Provenance & Evidence