Hydrochloric Acid → HCID 66918945, compound

HRID 2354232Notes

Reaction equation

HRID 2354232 reaction equation
[CH:1]1([NH:4][C:5](=[O:33])[C:6]2[CH:11]=[CH:10][C:9]([CH3:12])=[C:8]([N:13]3[C:22](=[O:23])[C:21]4[C:16](=[CH:17][CH:18]=[C:19]([N:24]5[CH2:29][CH2:28][N:27]([CH:30]([CH3:32])[CH3:31])[CH2:26][CH2:25]5)[CH:20]=4)[N:15]=[CH:14]3)[CH:7]=2)[CH2:3][CH2:2]1.[ClH:34]>C(OCC)(=O)C.O1CCOCC1>[ClH:34].[CH:1]1([NH:4][C:5](=[O:33])[C:6]2[CH:11]=[CH:10][C:9]([CH3:12])=[C:8]([N:13]3[C:22](=[O:23])[C:21]4[C:16](=[CH:17][CH:18]=[C:19]([N:24]5[CH2:25][CH2:26][N:27]([CH:30]([CH3:31])[CH3:32])[CH2:28][CH2:29]5)[CH:20]=4)[N:15]=[CH:14]3)[CH:7]=2)[CH2:3][CH2:2]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 11751183HCID 11751183, compound

Product 1

HCID 66918945HCID 66918945, compound

Reagents, catalysts & solvents 2

HCID 8857Ethyl AcetateSolventHCID 312751,4-DioxaneSolvent

Procedure

To a stirred solution of N-cyclopropyl-3-[6-(4-isopropylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]-4-methylbenzamide (0.010 g) in ethyl acetate (0.5 ml) was added a 4N HCl in dioxane (0.0056 ml) at room temperature. The mixture was stirred at room temperature for a further 30 minutes. The reaction mixture was evaporated to give the title compound; NMR Spectrum: (DMSOd6) 0.55 (m, 2H), 0.70 (m, 2H), 1.24 (m, 6H), 2.13 (s, 3H), 2.85 (m, 1H), 3.00-3.50 (m, 9H), 7.53 (m, 2H), 7.69 (m, 2H), 7.84 (s, 1H), 7.91 (d, 1H), 8.12 (s, 1H), 8.46 (d, 1H), 10.80 (br s, 1H).

Workup

  1. customThe reaction mixture was evaporated

Sources & evidence

ORD record
ord-83235016b4cc4e33b1b958e03e682c55
Source dataset
uspto-grants-2010_07
Patent number
US07750154B2

Reaction notes

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