Hydrochloric Acid → n-Cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4h)-yl]benzamide hydrochloride salt

Participants

Reaction Steps

Using an analogous procedure to that described in Example 45, 4N HCl in dioxane was reacted with N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]benzamide to gave the title compound; NMR Spectrum: (DMSOd6) 0.57 (m, 2H), 0.70 (m, 2H), 2.14 (s, 3H), 2.82 (d, 3H), 2.87 (m, 1H), 3.22 (m, 4H), 3.52 (d, 2H), 4.01 (m, 2H), 7.53 (d, 1H), 7.58 (d, 1H), 7.70 (m, 2H), 7.85 (s, 1H), 7.92 (m, 1H), 8.17 (s, 1H), 8.48 (d, 1H), 11.05 (s, 1H).

Provenance & Evidence