Hydrochloric Acid → n-Cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4h)-yl]benzamide hydrochloride salt

HRID 2354233Notes

Reaction equation

HRID 2354233 reaction equation
[ClH:1].[CH:2]1([NH:5][C:6](=[O:32])[C:7]2[CH:12]=[CH:11][C:10]([CH3:13])=[C:9]([N:14]3[C:23](=[O:24])[C:22]4[C:17](=[CH:18][CH:19]=[C:20]([N:25]5[CH2:30][CH2:29][N:28]([CH3:31])[CH2:27][CH2:26]5)[CH:21]=4)[N:16]=[CH:15]3)[CH:8]=2)[CH2:4][CH2:3]1>O1CCOCC1>[ClH:1].[CH:2]1([NH:5][C:6](=[O:32])[C:7]2[CH:12]=[CH:11][C:10]([CH3:13])=[C:9]([N:14]3[C:23](=[O:24])[C:22]4[C:17](=[CH:18][CH:19]=[C:20]([N:25]5[CH2:26][CH2:27][N:28]([CH3:31])[CH2:29][CH2:30]5)[CH:21]=4)[N:16]=[CH:15]3)[CH:8]=2)[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11373432Azd-6703

Product 1

HCID 66919091n-Cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4h)-yl]benzamide hydrochloride salt

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Using an analogous procedure to that described in Example 45, 4N HCl in dioxane was reacted with N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]benzamide to gave the title compound; NMR Spectrum: (DMSOd6) 0.57 (m, 2H), 0.70 (m, 2H), 2.14 (s, 3H), 2.82 (d, 3H), 2.87 (m, 1H), 3.22 (m, 4H), 3.52 (d, 2H), 4.01 (m, 2H), 7.53 (d, 1H), 7.58 (d, 1H), 7.70 (m, 2H), 7.85 (s, 1H), 7.92 (m, 1H), 8.17 (s, 1H), 8.48 (d, 1H), 11.05 (s, 1H).

Sources & evidence

ORD record
ord-00fe5dde00a44e10af0a31e7494ebe75
Source dataset
uspto-grants-2010_07
Patent number
US07750154B2

Reaction notes

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