Methanesulfonic Acid → HCID 86610970, compound

Participants

Reaction Steps

Using an analogous procedure to that described in Example 45, two equivalents of 1N methanesulfonic acid in ethyl acetate was reacted with N-cyclopropyl-3-[6-{[2-(dimethylamino)ethyl]thio}-4-oxoquinazolin-3(4H)-yl]-4-methylbenzamide to gave the title compound; NMR Spectrum: (DMSOd6) 0.62 (m, 2H), 0.76 (m, 2H), 2.21 (s, 3H), 2.47 (s, 6H), 2.89 (d, 6), 2.93 (m, 1H), 3.37 (m, 2H), 3.52 (m, 2H), 7.60 (d, 1H), 7.84 (d, 1H), 7.90 (d, 1H), 7.99 (m, 2H), 8.20 (d, 1H), 8.40 (s, 1H), 8.52 (d, 1H), 9.58 (s, 1H).

Provenance & Evidence