Methanesulfonic Acid → HCID 86610970, compound

HRID 2354242Notes

Reaction equation

HRID 2354242 reaction equation
[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[CH:6]1([NH:9][C:10](=[O:35])[C:11]2[CH:16]=[CH:15][C:14]([CH3:17])=[C:13]([N:18]3[C:27](=[O:28])[C:26]4[C:21](=[CH:22][CH:23]=[C:24]([S:29][CH2:30][CH2:31][N:32]([CH3:34])[CH3:33])[CH:25]=4)[N:20]=[CH:19]3)[CH:12]=2)[CH2:8][CH2:7]1>C(OCC)(=O)C>[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[CH:6]1([NH:9][C:10](=[O:35])[C:11]2[CH:16]=[CH:15][C:14]([CH3:17])=[C:13]([N:18]3[C:27](=[O:28])[C:26]4[C:21](=[CH:22][CH:23]=[C:24]([S:29][CH2:30][CH2:31][N:32]([CH3:34])[CH3:33])[CH:25]=4)[N:20]=[CH:19]3)[CH:12]=2)[CH2:8][CH2:7]1

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 66919015HCID 66919015, compound

Product 1

HCID 86610970HCID 86610970, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Using an analogous procedure to that described in Example 45, two equivalents of 1N methanesulfonic acid in ethyl acetate was reacted with N-cyclopropyl-3-[6-{[2-(dimethylamino)ethyl]thio}-4-oxoquinazolin-3(4H)-yl]-4-methylbenzamide to gave the title compound; NMR Spectrum: (DMSOd6) 0.62 (m, 2H), 0.76 (m, 2H), 2.21 (s, 3H), 2.47 (s, 6H), 2.89 (d, 6), 2.93 (m, 1H), 3.37 (m, 2H), 3.52 (m, 2H), 7.60 (d, 1H), 7.84 (d, 1H), 7.90 (d, 1H), 7.99 (m, 2H), 8.20 (d, 1H), 8.40 (s, 1H), 8.52 (d, 1H), 9.58 (s, 1H).

Sources & evidence

ORD record
ord-b3279ddbb9994ef2bdbe35dd47de0f30
Source dataset
uspto-grants-2010_07
Patent number
US07750154B2

Reaction notes

Loading…