Methanesulfonic Acid → HCID 86610972, compound

Participants

Reaction Steps

Using an analogous procedure to that described in Example 45, two equivalents of 1N methanesulfonic acid in ethyl acetate was reacted N-cyclopropyl-4-methyl-3-[4-oxo-6-(2-piperidin-1-ylethoxy)quinazolin-3(4H)-yl]benzamide to gave the title compound; NMR Spectrum: (DMSOd6) 0.57 (m, 2H), 0.71 (m, 2H), 1.56 (s, 2H), 1.76 (s, 4H), 2.14 (s, 3H), 2.32 (s, 3H), 2.86 (m, 1H), 3.09 (m, 2H), 3.31 (m, 4H), 4.44 (s, 2H), 7.56 (m, 2H), 7.67 (d, 1H), 7.78 (d, 1H), 7.85 (s, 1H), 7.91 (d, 1H), 8.22 (s, 1H), 8.45 (d, 1H).

Provenance & Evidence