Methanesulfonic Acid → HCID 86610972, compound

HRID 2354244Notes

Reaction equation

HRID 2354244 reaction equation
[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[CH:6]1([NH:9][C:10](=[O:38])[C:11]2[CH:16]=[CH:15][C:14]([CH3:17])=[C:13]([N:18]3[C:27](=[O:28])[C:26]4[C:21](=[CH:22][CH:23]=[C:24]([O:29][CH2:30][CH2:31][N:32]5[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]5)[CH:25]=4)[N:20]=[CH:19]3)[CH:12]=2)[CH2:8][CH2:7]1>C(OCC)(=O)C>[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[CH:6]1([NH:9][C:10](=[O:38])[C:11]2[CH:16]=[CH:15][C:14]([CH3:17])=[C:13]([N:18]3[C:27](=[O:28])[C:26]4[C:21](=[CH:22][CH:23]=[C:24]([O:29][CH2:30][CH2:31][N:32]5[CH2:33][CH2:34][CH2:35][CH2:36][CH2:37]5)[CH:25]=4)[N:20]=[CH:19]3)[CH:12]=2)[CH2:7][CH2:8]1

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 11328301HCID 11328301, compound

Product 1

HCID 86610972HCID 86610972, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Using an analogous procedure to that described in Example 45, two equivalents of 1N methanesulfonic acid in ethyl acetate was reacted N-cyclopropyl-4-methyl-3-[4-oxo-6-(2-piperidin-1-ylethoxy)quinazolin-3(4H)-yl]benzamide to gave the title compound; NMR Spectrum: (DMSOd6) 0.57 (m, 2H), 0.71 (m, 2H), 1.56 (s, 2H), 1.76 (s, 4H), 2.14 (s, 3H), 2.32 (s, 3H), 2.86 (m, 1H), 3.09 (m, 2H), 3.31 (m, 4H), 4.44 (s, 2H), 7.56 (m, 2H), 7.67 (d, 1H), 7.78 (d, 1H), 7.85 (s, 1H), 7.91 (d, 1H), 8.22 (s, 1H), 8.45 (d, 1H).

Sources & evidence

ORD record
ord-6a0a8d101c7f4abeac3b2a5a30d63909
Source dataset
uspto-grants-2010_07
Patent number
US07750154B2

Reaction notes

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