反应详情

5-Methyl-4-(methyloxy)-2-nitrophenol (3.65 g, 20 mmol) was dissolved in EtOAc (100 mL) and 200 mg of 5% Pd/C was added. The reaction vessel was evacuated and filled with N2. This process was repeated twice then filled with H2 at 1 atm, and stirred for 16 h. The mixture was filtered through a pad of celite, washed with EtOAc, and the solvent was removed via rotovap to give the title compound (3.0 g, 98%) as a white solid. MS (ES) m/e 154 [M+H]+.

1. customThe reaction vessel was evacuated
2. additionfilled with N2
3. additionThis process was repeated twice then filled with H2 at 1 atm
4. filtrationThe mixture was filtered through a pad of celite
5. washwashed with EtOAc
6. customthe solvent was removed via rotovap