反应详情

To a solution of 4-(4-chlorophenyl)-3-(3-cyanophenyl)-2-butanol (1.0 kg, 3.5 mol) in toluene (10 L) at 0° C. was added triethylamine (684 mL, 4.9 mol) and methanesulfonyl chloride (353 mL, 4.6 mol). After stirring for 5 min, the reaction mixture was filtered, and the precipitate was washed with toluene (8 L). The filtrate was washed with sodium bicarbonate (6 L, 50% saturated aqueous solution) and water (3 L), and concentrated to give the title compound.

1. filtrationthe reaction mixture was filtered
2. washthe precipitate was washed with toluene (8 L)
3. washThe filtrate was washed with sodium bicarbonate (6 L, 50% saturated aqueous solution) and water (3 L)
4. concentrationconcentrated