2-Bromopyridine → HCID 12342940, compound

HRID 2354553Notes

Reaction equation

HRID 2354553 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[NH2:8][C:9]1[S:13][C:12]2[CH2:14][CH2:15][CH2:16][CH2:17][C:11]=2[C:10]=1[C:18](OCC)=[O:19]>>[CH2:17]1[C:11]2[C:10]3[C:18](=[O:19])[N:3]4[CH:4]=[CH:5][CH:6]=[CH:7][C:2]4=[N:8][C:9]=3[S:13][C:12]=2[CH2:14][CH2:15][CH2:16]1

Participants

3

Reactant 2

HCID 79732-BromopyridineHCID 78262Ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

Product 1

HCID 12342940HCID 12342940, compound

Procedure

2-Bromopyridine and ethyl 2-amino-4,5,6,7-tetrahydrobenzo(b)thiophene-3-carboxylate 1b were heated to 165° C. for three and half hours under argon. After cooling the solid material was crystallized from EtOH. The crystallised product was purified by flash chromatography using CH2Cl2/EtOAc 9:1 as an eluent.

Workup

  1. temperatureAfter cooling the solid material
  2. customwas crystallized from EtOH
  3. customThe crystallised product was purified by flash chromatography

Sources & evidence

ORD record
ord-0ee141009e5c43acb967ed5e8e56dd81
Source dataset
uspto-grants-2010_07
Patent number
US07754709B2

Reaction notes

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