Ethylene Glycol → HCID 67263330, compound

HRID 2354830Notes

Reaction equation

HRID 2354830 reaction equation
[Na].Cl[C:3]1[N:11]=[C:10]2[C:6]([N:7]=[CH:8][N:9]2[CH2:12][C:13]2[CH:14]=[N:15][C:16]([CH3:19])=[CH:17][CH:18]=2)=[C:5]([NH2:20])[N:4]=1.O.[CH2:22]([OH:25])[CH2:23][OH:24]>>[OH:24][CH2:23][CH2:22][O:25][C:3]1[N:11]=[C:10]2[C:6]([N:7]=[CH:8][N:9]2[CH2:12][C:13]2[CH:14]=[N:15][C:16]([CH3:19])=[CH:17][CH:18]=2)=[C:5]([NH2:20])[N:4]=1

Participants

5

Reactant 4

HCID 174Ethylene GlycolHCID 962WaterHCID 5360545SodiumHCID 23079478HCID 23079478, compound

Product 1

HCID 67263330HCID 67263330, compoundYield 94%

Conditions

Temperature
100 °C

Procedure

After sodium (2.1 g, 91 mmol) was dissolved in ethylene glycol (30 ml), 2-chloro-9-{(6-methyl3-pyridyl)methyl}adenine (3.0 g, 11 mmol) was added thereto and the mixture was stirred at 100° C. for 3 hours. After the mixture was allowed to cool, water (80 ml) was added thereto and the resulting precipitate was filtered to give the captioned compound (3.1 g, 10 mmol, yield: 94%) as a white solid.

Workup

  1. temperatureto cool
  2. filtrationthe resulting precipitate was filtered

Sources & evidence

ORD record
ord-9f649b5f7b98481f8961e7804d82c7fb
Source dataset
uspto-grants-2010_07
Patent number
US07754728B2

Reaction notes

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