Ethyl 4-piperidinecarboxylate → HCID 178450378, compound

HRID 2354842Notes

Reaction equation

HRID 2354842 reaction equation
[CH2:1]([O:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:23]C)[N:12]2[CH2:15][C:16]2[CH:17]=[N:18][C:19](Cl)=[CH:20][CH:21]=2)=[C:8]([NH2:25])[N:7]=1)[CH2:2][CH2:3][CH3:4].[CH2:26]([O:28][C:29]([CH:31]1[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]1)=[O:30])[CH3:27]>C(O)C>[CH2:1]([O:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([OH:23])[N:12]2[CH2:15][C:16]2[CH:17]=[N:18][C:19]([N:34]3[CH2:35][CH2:36][CH:31]([C:29]([O:28][CH2:26][CH3:27])=[O:30])[CH2:32][CH2:33]3)=[CH:20][CH:21]=2)=[C:8]([NH2:25])[N:7]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 70770Ethyl 4-piperidinecarboxylateHCID 10292152HCID 10292152, compound

Product 1

HCID 178450378HCID 178450378, compoundYield 44%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-Butoxy-9-(6-chloro-3-pyridylmethyl)-8-methoxyadenine (0.28 mg, 0.77 mmol) was added to 4-ethoxycarbonylpiperidine (10 ml), and the mixture was refluxed under stirring for 8 hours. After the mixture was allowed to cool, ethanol was added thereto. The resulting solid was filtered and purified by column chromatography (SiO2 20 g, eluting solvent: CHCl3/MeOH=80/1˜20/1) to give the captioned compound (0.15 g, 1.41 mmol, yield: 44%) as a white solid.

Workup

  1. temperaturethe mixture was refluxed
  2. temperatureto cool
  3. filtrationThe resulting solid was filtered
  4. custompurified by column chromatography (SiO2 20 g, eluting solvent: CHCl3/MeOH=80/1˜20/1)

Sources & evidence

ORD record
ord-14f1d4a64f7a49ffb4470cfeb53e93d3
Source dataset
uspto-grants-2010_07
Patent number
US07754728B2

Reaction notes

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